Orthodontics and Periodontics interaction contribute synergically to the adult and children treatment plan. Orthodontic procedures can improve the periodontal treatment plan, increase its predictability, integrate it, interact in the surgical approach. Orthodontics is, definitely, a periodontal treatment. At the same time, Periodontics can increase the potential and predictability of orthodontic treatments, completing them synergically. The key elements of diagnosis, treatment planning and protocols in ortho-perio patients can be achieved in vestibular, lingual and aligner orthodontic techniques, focusing on a flow chart integrated with risk assessment and inserted in timing in daily practice with strict compliance to the biomechanics in periodontal patients. The “Guided Orthodontic Regeneration” (GOR) procedures use orthodontic movements in perio-restorative patients. GOR techniques include a guided orthodontic “soft tissues” regeneration (GOTR) with a plastic approach of the soft tissues and a guided orthodontic “bone” regeneration (GOBR) with a new approach to bone regeneration. The increased amount of soft tissue acquired with orthodontic movement can be used for subsequent periodontal regenerative surgical techniques, improving their management. The increased amount of bone improves the primary stability of the implant and makes a regenerative technique more predictable to regenerate lost tissue, to restore teeth with external resorption in the aesthetic zone or to create new hard and soft tissue for adjacent teeth. Orthodontic bone leveling, space redistribution, modification of the morphology of bone defects can modify interdisciplinary treatments and integrate the adult periodontal approach. On the other hand, the periodontal approach in diagnosis, treatment planning, and orthodontic mechanics in children and adolescents represents a revolution that must become an integral part of daily orthodontic practice in relationship to the prevention of major periodontal pathologies in paediatric and adolescent patients and to the highlighting of the importance of periodontal screening to enable early detection of both dental and systemic issues.